Improved outcome of women after liver resection is predominantly hepatocellular carcinoma dependent

Presenter: Gabriel De la Cruz Ku MD | Mayo Clinic, Rochester Background: Estrogen has been documented to be of critical promoter liver regeneration after partial hepatectomy in rodent models. While exploratory data suggested that female patients shown an increased regenerative response portal vein embolization, only very limited human exist would support the relevance estrogen humans. Our aim was assess influence sex on outcomes resection. Methods: Assessing NSQIP database, we included undergoing hepatic resection from 2014 2017 with preoperative blood values and detailed postoperative outcome. Patients were grouped according dysfunction(LD), morbidity mortality. Only pre-operative surgical variables analysis. We determined association between study (LD, mortality, major complications) using a logistic regression crude multivariate models, further analyses performed subgroups interest. Results: A total 13,401 underwent elective Sex equally distributed (point percentage difference: 0.72). Mean age 58 years(SD±13.52). The most frequent diagnoses colorectal cancer metastases(CRCLM) (42.6%), followed by hepatocellular carcinoma(HCC) (17.6%), cholangiocarcinoma(CCC) (13.0%), benign tumor(9.8%), other metastases(5.2%), infections(1.2%). In comparison females, males older (60.72 vs.56.28y) suffered more frequently diabetis (21.0%vs.13.5%), COPD(4.2%vs.2.9%), CHF (0.5%vs.0.02%), bleeding disorder(3.7%vs2.3%) as well higher bilirubin, GOT, INR, creatinine lower platelets had ASA operative time. Moreover, frequency CRCLM HCC. LD, death at 30 days complications occurred 4.6%, 1.6% 15.1%, respectively. After controlling for above mentioned potential confounders, male independent predictor LD (OR=1.48, 95% CI:1.16-1.91), (OR=1.28, CI:1.10-1.48), mortality (OR=1.65, CI:1.06-2.59). Upon multivariable analyses, observed seemed have effects outcome CCC, while suffering HCC associated than 3 time risk (OR=3.08, 95%CI:1.50-6.34). Conclusion: able document seems significantly affect general population subgroups. Indeed, upon analyses. Its impact HCC, times LD. might particular during post-hepatectomy underlying disease, it is present but also explained fact differ types disease compared men. particular, recent evidence suggest NASH represent cause women men alcoholic or viral hepatitis still predominate. awareness about these based differences help guide strategy adequate stratification clinical scores including component improve assessment decision-making, particularly patients.